Examining the Relationship Between Confusion and Learning: A Descriptive Meta-Analysis

Previous research into confusion and learning neglects to investigate how this relationship varies when faced with impact factors such as multiple types of affect and learning measurements, learning environment, or grade level. Moreover, past research also reports di-verse effect size values for this relationship, making the correlation ambiguous. As such, the current research seeks to reconcile these nuances between confusion and learning through a meta-analytic approach. In this analysis, it was found that there was no relationship between confusion and learning gains, or in the subgroup analysis of grade level. Since only one impact factor, grade level, was analyzed, it is considered that the analysis of other or multiple impact factors could help to further understand the association between confusion and learning. It is also reasoned that variability in the definitions of confusion and learning in the papers included in the meta-analysis as well as publication bias contribute to this result. As such, future research may choose to investigate these avenues and continued research generally into the association between confusion and learning would also be helpful to better understand this relationship

Automated Gaze-Based Mind Wandering Detection during Computerized Learning in Classrooms

We investigate the use of commercial off-the-shelf (COTS) eye-trackers to automatically detect mind wandering—a phenomenon involving a shift in attention from task-related to task-unrelated thoughts—during computerized learning. Study 1 (N = 135 high-school students) tested the feasibility of COTS eye tracking while students learn biology with an intelligent tutoring system called GuruTutor in their classroom. We could successfully track eye gaze in 75% (both eyes tracked) and 95% (one eye tracked) of the cases for 85% of the sessions where gaze was successfully recorded. In Study 2, we used this data to build automated student-independent detectors of mind wandering, obtaining accuracies (mind wandering F1 = 0.59) substantially better than chance (F1 = 0.24). Study 3 investigated context-generalizability of mind wandering detectors, finding that models trained on data collected in a controlled laboratory more successfully generalized to the classroom than the reverse. Study 4 investigated gaze- and video- based mind wandering detection, finding that gaze-based detection was superior and multimodal detection yielded an improvement in limited circumstances. We tested live mind wandering detection on a new sample of 39 students in Study 5 and found that detection accuracy (mind wandering F1 = 0.40) was considerably above chance (F1 = 0.24), albeit lower than offline detection accuracy from Study 1 (F1 = 0.59), a finding attributable to handling of missing data. We discuss our next steps towards developing gaze-based attention-aware learning technologies to increase engagement and learning by combating mind wandering in classroom contexts

Translation of upstream open reading frames in a model of neuronal differentiation

Abstract Background Upstream open reading frames (uORFs) initiate translation within mRNA 5′ leaders, and have the potential to alter main coding sequence (CDS) translation on transcripts in which they reside. Ribosome profiling (RP) studies suggest that translating ribosomes are pervasive within 5′ leaders across model systems. However, the significance of this observation remains unclear. To explore a role for uORF usage in a model of neuronal differentiation, we performed RP on undifferentiated and differentiated human neuroblastoma cells. Results Using a spectral coherence algorithm (SPECtre), we identify 4954 consistently translated uORFs across 31% of all neuroblastoma transcripts. These uORFs predominantly utilize non-AUG initiation codons and exhibit translational efficiencies (TE) comparable to annotated coding regions. On a population basis, the global impact of both AUG and non-AUG initiated uORFs on basal CDS translation were small, even when analysis is limited to conserved and consistently translated uORFs. However, uORFs did alter the translation of a subset of genes, including the Diamond-Blackfan Anemia associated ribosomal gene RPS24. With retinoic acid induced differentiation, we observed an overall positive correlation in translational shifts between uORF/CDS pairs. However, CDSs downstream of uORFs show smaller shifts in TE with differentiation relative to CDSs without a predicted uORF, suggesting that uORF translation buffers cell state dependent fluctuations in CDS translation. Conclusion This work provides insights into the dynamic relationships and potential regulatory functions of uORF/CDS pairs in a model of neuronal differentiation.https://deepblue.lib.umich.edu/bitstream/2027.42/149183/1/12864_2019_Article_5775.pd

Instructor presence effect: Liking does not always lead to learning

The final publication is available at Elsevier via https://dx.doi.org/10.1016/j.compedu.2018.03.011 © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/Online education provides the opportunity to present lecture material to students in different formats or modalities, however there is debate about which lecture formats are best. Here, we conducted four experiments with 19–68 year old online participants to address the question of whether visuals of the instructor in online video lectures benefit learning. In Experiments 1 (N = 168) and 2 (N = 206) participants were presented with a lecture in one of three modalities (audio, audio with text, or audio with visuals of the instructor). Participants reported on their attentiveness – mind wandering (MW) – throughout the lecture and then completed a comprehension test. We found no evidence of an advantage for video lectures with visuals of the instructor in terms of a reduction in MW or increase in comprehension. In fact, we found evidence of a comprehension cost, suggesting that visuals of instructors in video lectures may act as a distractor. In Experiments 3 (N = 88) and 4 (N = 109) we explored learners' subjective evaluations of lecture formats across 4 different lecture formats (audio, text, audio + text, audio + instructor, audio + text + instructor). The results revealed learners not only find online lectures with visuals of the instructor more enjoyable and interesting, they believe this format most facilitates their learning. Taken together, these results suggest visuals of the instructor potentially impairs comprehension, but learners prefer and believe they learn most effectively with this format. We refer to as the Instructor Presence Effect and discuss implications for multimedia learning and instructional design.Social Sciences and Humanities Research Council of Canada SSHRC) Insight Discovery Grant (70104)Canada Research Chairs program (056562)Early Researcher Award from the Province of Ontario (058402)Natural Sciences and Engineering Research Council of Canada (NSERC) Discovery Grant (RGPIN-2014-06459

Overview of Australian Indigenous health status, 2014

The main purpose of the Overview is to provide a comprehensive summary of the most recent indicators of the health and current health status of Australia’s Aboriginal and Torres Strait Islander peoples. It has been prepared by the Australian Indigenous HealthInfoNet as a part of our contribution to ‘closing the gap’ in health between Aboriginal and Torres Strait Islander people and other Australians by making relevant, high quality knowledge and information easily accessible to policy makers, health service providers, other health professionals including Health workers, program managers, clinicians, researchers, students and the general community. The initial sections of this Overview provide information about the context of Aboriginal and Torres Strait Islander health, Aboriginal and Torres Strait Islander population, and various measures of population health status. Most of the subsequent sections about specific health conditions comprise an introduction about the condition and evidence of the current burden of the condition among Aboriginal and Torres Strait Islander people. Information is provided for state and territories and for demographics such as gender and age when it is available and appropriate. While the Overview provides a comprehensive review of key indicators across a range of health topics, it is beyond the scope to provide detailed information on other aspects, such as the availability and use of services (including barriers to their use) and strategies and policies related to specific health topics. Interested readers should refer to the topic-specific reviews that are available on the HealthInfoNet’s website. Additional, more in depth, information about the topics summarised in this Overview is included in the corresponding sections of the HealthInfoNet’s website (www.healthinfonet.ecu.edu.au). There are a number of additions to this Overview. We have included a recognition statement, a note on the use of appropriate terminology that introduces our guidelines on the matter, and a statement of commitment to enhancing our strengths based approach to reporting

Overview of Aboriginal and Torres Strait Islander health status, 2017

The Overview of Aboriginal and Torres Strait Islander health status (Overview) aims to provide a comprehensive summary of the most recent indicators of the health and current health status of Australia’s Aboriginal and Torres Strait Islander people. The initial sections of the Overview provide information about the context of Aboriginal and Torres Strait Islander health, population, and various measures of population health status. The remaining sections are about selected health conditions and risk and protective factors that contribute to the overall health of Aboriginal and Torres Strait Islander people. These sections comprise an introduction and evidence of the extent of the condition or risk/protective factor. The annual Overview is a resource relevant for workers, students and others who need to access up-to-date information about Aboriginal and Torres Strait Islander health

Overview of Aboriginal and Torres Strait Islander health status, 2015

The main purpose of the Overview is to provide a comprehensive summary of the most recent indicators of the health and current health status of Australia’s Aboriginal and Torres Strait Islanders people. It has been prepared by Australian Indigenous HealthInfoNet staff as part of our contribution to supporting those who work in the Aboriginal and Torres Strait Islander health sector. The Overview is a key element of the HealthInfoNet commitment to authentic and engaged knowledge development and exchange. The initial sections of this Overview provide information about the context of Aboriginal and Torres Strait Islander health, population, and various measures of population health status. Most of the subsequent sections about specific health conditions comprise an introduction about the condition and evidence of the current burden of the condition among Aboriginal and Torres Strait Islander people. Information is provided for state and territories and for demographics such as sex and age when it is available and appropriate

Overview of Australian Aboriginal and Torres Strait Islander health status 2016

This report provides a comprehensive overview of the most recent indicators of the health and wellbeing of Aboriginal and Torres Strait Islander people. Information focuses on: Aboriginal and Torres Strait Islander populations the context of Aboriginal and Torres Strait Islander health various measures of population health status selected health conditions health risk and protective factors. The Overview shows that the health of Aboriginal and Torres Strait Islander people continues to improve slowly and there has been a decline in the death rates for Aboriginal and Torres Strait Islander people and also a significant closing of the gap in death rates between Aboriginal and Torres Strait Islander and non-Indigenous people. The infant mortality rate has declined significantly. There have also been improvements in a number of areas contributing to health status such as the proportion of Aboriginal and Torres Strait Islander mothers who smoked during pregnancy has decreased. There has been a slight decrease in the proportion of low birth weight babies born to Aboriginal and Torres Strait Islander mothers between 2004 and 2014. Age-standardised death rates for respiratory disease in NSW, Qld, WA, SA and NT declined by 26% over the period 1998-2012 for Aboriginal and Torres Strait Islander people. Two new sections are featured in this edition of the Overview. With the 20th anniversary of the Bringing them home report, a section has been dedicated to Healing which highlights the contribution of healing workers and organisations to supporting people, families and communities impacted by the Stolen Generations. Environmental health with its important link to the social determinants of health is also included for the first time in the Overview 2016

Heterogeneity and Clonal Evolution of Acquired PARP Inhibitor Resistance in TP53- and BRCA1-Deficient Cells

Homologous recombination (HR)-deficient cancers are sensitive to poly- ADP ribose polymerase inhibitors (PARPi), which have shown clinical efficacy in the treatment of high-grade serous cancers (HGSC). However, the majority of patients will relapse, and acquired PARPi resistance is emerging as a pressing clinical problem. Here we generated seven single-cell clones with acquired PARPi resistance derived from a PARPi-sensitive TP53(-/-) and BRCA1(-/-) epithelial cell line generated using CRISPR/Cas9. These clones showed diverse resistance mechanisms, and some clones presented with multiple mechanisms of resistance at the same time. Genomic analysis of the clones revealed unique transcriptional and mutational profiles and increased genomic instability in comparison with a PARPi-sensitive cell line. Clonal evolutionary analyses suggested that acquired PARPi resistance arose via clonal selection from an intrinsically unstable and heterogenous cell population in the sensitive cell line, which contained preexisting drug-tolerant cells. Similarly, clonal and spatial heterogeneity in tumor biopsies from a clinical patient with BRCA1-mutant HGSC with acquired PARPi resistance was observed. In an imaging-based drug screening, the clones showed heterogenous responses to targeted therapeutic agents, indicating that not all PARPi-resistant clones can be targeted with just one therapy. Furthermore, PARPi-resistant clones showed mechanism-dependent vulnerabilities to the selected agents, demonstrating that a deeper understanding on the mechanisms of resistance could lead to improved targeting and biomarkers for HGSC with acquired PARPi resistance. Significance: This study shows that BRCA1-deficient cells can give rise to multiple genomically and functionally heterogenous PARPi-resistant clones, which are associated with various vulnerabilities that can be targeted in a mechanism-specific manner.Peer reviewe